Our research project is the first to study the uncoupling of obesity and chronic inflammation in relation to Type II Diabetes. We will be using various, well-known lab techniques to test the hypothesis that the Yup'ik polyunsaturated fatty acid, PUFA-rich, traditional diet may lower chronic inflammation despite the high prevalence of obesity. Obesity is associated with changes in levels of neuroendocrine mediators that are present in blood circulation and are able to readily reach microvascular endothelial cells, inducing a variety of responses. The response we are currently studying is angiogenesis. The Endothelial Cell Tube Formation Assay allows us to study the effect of AN blood plasma on angiogenesis.
Hypothesis: Blood plasma samples from AN people containing high PUFAs would inhibit inflammation, low PUFAs would stimulate inflammatory response.
Students involved: Sasha White, Alexander Thompson